In 2007,Japanese scholars reported the selective antioxidant effect of hydrogen in Nature Medicine, prompting Chinese researchers to engage in hydrogen biology studies. Since 2018, Professor Xu Kecheng and his team have conducted real-world retrospective and prospective studies on hydrogen for cancer control, publishing Hydrogen Cancer Controlin 2019.

Current understanding suggests hydrogen inhibits tumor cell proliferation and invasion via antioxidant and anti- inflammatory mechanisms. Recent research shows it also aids cancer adjuvant therapy by suppressing tumor angiogenesis, improving tumor hypoxia, and regulating immunity. Additionally, hydrogen mitigates chemoradiotherapy side effects without reducing antitumor efficacy, supporting combined hydrogen-included cancer therapies.

Four Antitumor Mechanisms of Hydrogen

√ Inhibiting cancer cell proliferation and invasiveness: Hydrogen selectively scavenges toxic oxygen free

radicals in tumor cells and regulates cell signaling pathways to curb the abnormal division of cancer cells and

their ability to spread to surrounding tissues.

√ Regulating anti-tumor immune function: Hydrogen restores the mitochondrial function of immune cells

(such as T cells), relieves immunosuppression, and enhances the body's ability to recognize and attack tumor

cells.

√ Inhibiting tumor angiogenesis: Hydrogen inhibits the expression and activity of pro-angiogenic factors (such

as VEGF), hinders the formation of new tumor blood vessels, and cuts off their nutrient supply.

√ Alleviating side effects of anti-cancer therapy: Hydrogen reduces damage to normal tissues caused by

radiotherapy, chemotherapy and other treatments through antioxidant and anti-inflammatory effects, and

relieves adverse reactions such as nausea and bone marrow suppression.

Hydrogen-oxygen inhalation protocol:

Inhale hydrogen-oxygen mixture at a flow rate of >3 L/min for >4-6 hours daily (administered in morning/noon/evening sessions or during sleep if non-disruptive).