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Why do tumor patients develop erythema and tingling in their hands and feet?

Beware of the occurrence of hand-foot syndrome.
 
With the use of chemotherapy and targeted drugs, patients not only experience typical adverse reactions such as liver and kidney damage, and bone marrow suppression but also encounter some skin-related adverse reactions. For example, itching, numbness, darkening of the skin, discoloration of the nails, and nail loss on the hands and feet. Beware, this may indicate the occurrence of hand-foot syndrome. Although it does not endanger the patient's life, it severely affects the patient's quality of life, leading to psychological fear and impacting anti-tumor treatment. So, how should we respond to this and detect and treat it early?

 
Concept of Hand-Foot Syndrome
Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysesthesia, is characterized by erythema of the hands and feet caused by chemotherapy. It is a characteristic cutaneous toxicity reaction related to chemotherapy. Symptoms initially manifest as numbness, tingling, and delayed sensation in the hands and feet, gradually progressing to desquamation, erosion, and ulceration. If left untreated, it can worsen, even forming blistering skin lesions, which can lead to unplanned reduction or discontinuation of chemotherapy or targeted drug dosage, affecting the effectiveness of treatment and survival, and reducing the patient's quality of life.
 
Prevention of Hand-Foot Syndrome - Conditions such as pressure, friction, trauma, and high temperature are all risk factors for inducing HFS.
1. Avoid local friction on the hands and feet, wear loose and soft gloves or socks;
2. Keep the skin moisturized, use moisturizers and creams to protect the skin after bathing with warm water;
3. Pay attention to keeping warm, avoid high temperatures or cold stimuli, such as soaking in hot water, or contact with ice water;
4. Avoid excessive sun exposure, use sunscreen when going out, and use umbrellas or hats to shade;
5. Eat a light diet, avoid spicy foods;
6. Maintain a daily water intake of more than 2500 ml to promote drug excretion from the body and reduce damage to the body;
7. Avoid skin trauma and prevent skin infections;
8. Once HFS occurs, immediately inform medical staff.
 
Hand-foot syndrome is a common adverse reaction to chemotherapy and targeted drugs and is not contagious to others. Hand-foot syndrome can be cured, and after cure, it does not affect daily life or the aesthetics of the hands and feet. Therefore, do not be afraid or fearful of it.

References
[1].席晨曦.强万敏等.化疗治疗引起的手足综合征管理现状及研究进展.[J].护理与康复.2023.22(5):94-97,102.
[2].彭雪.杨文博等.抗肿瘤药物诱导的手足综合征的诊疗进展.[J].现代肿瘤医学.2019.27(8):1461-1464.
[3].杨静.张利全.朱春兰.乳腺癌化疗患者所致手足综合征的预防管理循证实践.[J].齐鲁护理杂志.2024.30(1):105-108.
[4].马国洪.刘羽等.抗肿瘤药物所致手足综合征可能机制的研究进展.[J].河北医药.2023.(45)23:3645-3650.
[5].姚金娥.管静等.中药熏洗治疗抗肿瘤靶向药物所致手足综合征临床疗效研究[J].系统医学.2023.8(22):100-103.
[6].崔永佳.翁洁琼等.“干湿”辨证治疗抗肿瘤药物致手足皮肤不良反应.[J].世界科学技术-中医药现代化.2021.23(7):2487-2491.
[7].上海市医学会皮肤性病学分会.上海市医学会肿瘤靶分子专科分会.抗肿瘤药物相关皮肤不良反应管理管家共识.[J].中华皮肤杂志.2023.56(10):907-919.
 

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